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Anticancer Activities of Citrus Limonoids
Yu-Fu Zhou1,2, Yuan-Yuan Shen2, Zhi-Qin Zhou1*, Fu-Di Wang2*
1College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China;2Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Citrus， as one of the worldwide favorite fruits， draws more attention recently due to its therapeutic potentials. Limonoids， citrus secondary metabolites， have multiple bioactive functions， including anticancer， reducing cholesterol， anti-anxiety， antimicrobial， and antiviral activities. In last decades， people are struggling to seek for nontoxic chemo-preventing and chemo-therapeutic agents derived from foods. Mounting evidences support limonoids possesses potent anticancer activities among all sorts of fruits. This review summarizes the current knowledge of how limonoids eliminating free radicals， activating glutathione transferase (GST) enzymatic activity，inactivating carcinogen， and inhibiting tumor cell proliferation. It may pave a way to better understand the precise molecular mechanisms of limonoids anticancer activities.
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