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The Effect of Cyr1 Mutant in Sacharomyces cerevisiae Chronological Life Span
Ying Liu*, Guo-Li Wang, Qiang Bi, Hong-Xuan Xu
Department of Biochemistry and Molecular Biology, Basic Medical College, China Medical University, Shenyang 110001, China
Abstract: In order to investigate the effect of Cyr1 mutant in yeast life span extension， we measured Chronological life span， H2O2 or heat stress resistance and mitochondria morphology in DBY746 and Cyr1Δ. Compared with DBY746， Cyr1Δ had almost 2.25-fold life span extension. There was further extension of the life span of both strains under extreme CR. The 10% survial of DBY746 was 13 days and the Cyr1Δ was 45 days. The Cyr1Δ had more resistance to heat or hydrogen peroxide stress and relatively normal mitochondria membrane morphology than wild type at day 3 and day 5.
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