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The Use of the Elevated Plus Maze to Analyze Anxiety Behavior in Mice
Wei-Gang Wang1,2, Wen-Ting Wu3, Jia-Bin Zhou3, Hui-Min Yan3*
1Department of Chemistry, Tongji University, Shanghai 200092, China; 2School of Life Science and Technology, Tongji University,Shanghai 200092, China; 3Shanghai Research Center for Model Organisms, Shanghai 201203, China
Abstract: The elevated plus maze (EPM) is an important behavioral assay for rodents to assess the anxiety behavior. We introduced the basic principle and protocol of EPM. Mice are placed at the junction of the four arms facing the same open arm， activities were recorded by a video-tracking system. Both finished the test， but C57 showed less general activity than 129Sv. C57 mice showed significantly higher percent of closed/total time than the 129Sv. EPM is a simple and direct test to analyze anxiety behavior in mice.
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