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The Mechanism of Integrin Affinity Regulation
You-Dong Pan*, Kun Zhang, Jiao Yue, Jian-Feng Chen*
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Integrins are a family of α/β heterodimeric cell adhesion molecules that mediate cell-cell， cellmatrix and cell-pathogen interactions. They transmit signals bidirectionally across the plasma membrane and play key roles in development， immune responses， leukocyte trafficking， hemostasis， and cancer. The ligand binding affinity and signaling of integrin are regulated dynamically and precisely by different stimuli， and are associated with the conformational rearrangement of the integrin molecule. Moreover， the receptor function of integrin is regulated by different divalent cations. This article mainly focuses on the relationship between integrin function and its conformation， and the regulation of integrin function by divalent cations.
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