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The Regulation of Cell Junction Dynamics in the Mammalian Testis
Hong-Tao Jiang, Fang Liang, Zhu-Xiong Shao, Bao-Chang Zhu*
College of Life Science, Capital Normal University, Beijing 100048, China
Abstract: Spermatogenesis is a complex biochemical event， including dynamic change of cell junctions. This review illustrated the effects of cytokines and testosterone on cell junctions in the microenvironment of germ cell via paracrine regulation， including the maintaining of BTB and the moving of germ cell from basal compartment to apical compartment. The intricate role of cytokines and testosterone in regulating the transit of primary spermatocytes through the BTB has been discussed. We described herein an apical ES-BTB-hemidesmosome axis for local regulation within the seminiferous tubles. This may open a new research window for investigation in the field to tackle the functional regulation of spermatogenesis.
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