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Base Excision Repair and the Maintenance of Mycobacterium Genome Stability
Jin Hu, Jian-Ping Xie*
Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China
Abstract: The maintenance of genome stability is the crux for organism survival. Base excision repair (BER) is a major DNA repair pathway. This is particularly important for Mycobacterium tuberculosis and other intracellular pathogens. Fpg is the key enzyme in base excision repair. Mycobaterium genome comparison revealed that pathogenic M.tuberculosis harbor more genes involved in the BER than other mycobacteria. This might implicate that BER is closely related to the intracellular survival and pathogenesis of this bug. This justifies the BER pathway and crucial enzymes as promising targets for novel antibiotics.
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