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A New Anti-viral Molecule HIRRP Protein Interaction Screening， Validation and Biological Function Analysis
Lian-Qiu Wu, Song-Qing Tang, Yun Liao, Ying Zhang, Jie Chen, Wei Li, Cheng-Hong Dong, Long-Ding Liu, Qi-Han Li*
Institute of Medical Biology, Chinese Academy of Medical Science, Peking Union Medical College, Kunming 650118, China
Abstract: HSV-1 infection related repress protein (HIRRP) is a new protein with unknown structure and function. In our previous work， we found that HIRRP can obtain highly expression in Vero cells infected by HSV-1 and we speculated that HIRRP may take part in the event of anti-infection. However， the underlying mechanisms remain to be fully understood. Vitronectin (VTN) is a candidate molecule hold a relationship with HIRRP by yeast trap. We further demonstrated that VTN can react with HIRRP by Co-IP， fluorescence co-localization， cell proliferation and anti-virus analysis， and this reaction can gain a collaborative effect in anti-infection. Taken together， our data suggest that VTN can make relationships with HIRRP， and this relationship may act a function of anti-infection.
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