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Thymic Involution in Aging and Immune Reconstitution
Hong-Jing Yu1, Ming-Yuan Wu1, Di Xiang1, Yan Yu2*, Wei Han1*
1Laboratory of Regeneromics, School of pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China; 2Shanghai Municipality Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong Universi
Abstract: Aging is associated with involution of the thymus， leading to reduction in both T-cell development and emigration of naïve T cells to the periphery. Thymic involution leads to increased morbidity and mortality in many clinical settings. Considering of the negative consequences， it is important to understand the mechanisms driving thymic involution and homeostatic processes across the lifespan. There is growing evidence that the involution process of thymus might be therapeutically halted or reversed. We present here factors such as interleukin 7， keratinocyte growth factor and sex steroid ablation could be used for therapeutic thymus restoration and peripheral immune reconstitution.
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