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Role of Shh in Digit Development and Regulation of Its Expression
Hai-Min Tan, Lu-Hang Zhao*
Department of Biochemistry and Genetics, Medical College of Zhejiang University, Hangzhou 310058, China
Abstract: The process of human limb bud development is patterning process， Shh protein plays a key role as a morphogen of ZPA during the development of the limb bud. Cholesterol modification of Shh affects its diffusion to regulate digit 2 forming. After Shh expression， it affects digit 3 to digit 5 directly to regulate their forming without diffusion. However， digit 1 doesn’t need Shh in its development. Shh and other proteins(contain Gli family， Fgf family， Gremlin and so on) act with each other to form Fgf/Shh positive feedback loop and Fgf/Gremlin negative feedback loop， regulating the digital development.
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