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Adipose Tissue and Insulin Resistance
Hong-Bo Zhang, Qi-Qi Wan, Hua Liang, Feng Chen, Qin Wang*
School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China
Abstract: Adipose tissue can be divided into white adipose tissue and brown adipose tissue which， for a long time， has been considered only for body energy storage and non-shivering thermogenesis. However， during recent years， after the discovery of leptin， a lot of Adipose tissue’s new functions have been revealed. Apart from storing and releasing free fatty acid to get involved in energy metabolism， it also secretes a variety of adipocytokines to regulate peripheral tissue insulin sensitivity. More importantly， adipose tissue is closely related to chronic-metabolic- inflammation which directly leads to insulin resistance. This review provides an overview of connection between adipose tissue and insulin resistance from the aspects of free fatty acid， adipocytokines and inflammation.
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