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Establishment and Comparison of Three Types of Osteoarthritis in Mature Rats
Jing Wang1, Zhong-Hui Zhang1, Jiao-Meng Sun1, Chuan-Ying Xu2, Yan Yu2, Wei Han1*
1Laboratory of Regeneromics, School of Pharmacy Shanghai Jiao Tong University, Shanghai 200240, China; 2Shanghai Municipality Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong Universit
Abstract: The aim of this study was to establish three types of osteoarthritis animal model in Sprague- Dawley mature rats， and determin the effects and applications of three types of osteoarthritis animal models. Rats were randomly divided into Hulth model group， Mono-iodoacetate-induced group， anterior ligament resection model group and sham group. After several weeks of post-surgery， articular cartilages were dissected， embedded in paraffin， sectioned， and performed histological evaluation. The results showed that Hulth model and mono-iodoacetateinduced groups were successfully carried out， and osteoarthritis morphology and symptoms were observed at 6 weeks after surgery， which was similar to the advanced stage of osteoarthritis. Osteoarthritis symptoms were also found at more than 8 weeks after surgery in the anterior ligament resection model group， which was similar to the early or mid-stage of osteoarthritis. In conclusion， anterior ligament resection model was more suitable to investigate the development and pathogenesis of osteoarthritis and potential drug candidates research.
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