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The Progress on Long Non-coding RNA Function
Liang-He Yu, Nan Li, Shu-Qun Cheng*
Second Military Medical University, Shanghai 200438,China
Abstract: Most of the eukaryotic genome is transcribed， yielding a complex network of transcripts that includes tens of thousands of long noncoding RNAs with little or no protein-coding capacity. Although the vast majority of long noncoding RNAs have yet to be characterized thoroughly， there are probably many functions of long ncRNAs awaiting discovery. Multiple studies have shown that significant numbers of long ncRNAs are regulated during development， exhibit cell typespecific expression， localize to specific subcellular compartments， and are associated with human diseases. Here， we review the recent evolutions of long noncoding RNAs， their functions and medical significance.
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