Home > Browse Issues > Vol.31 No.4
Regulation and Function of Early Growth Response 1 during Mammalian Reproduction
Xiao-Huan Liang, Na-Xuan Qiu1, Zeng-Ming Yang*
College of Life Sciences, Northeast Agricultural University, Harbin 150030, China; 1Department of Obstetrics and Gynecology, First Hospital of Xiamen City, Xiamen 361003, China
Abstract: Early growth response 1 (Egr1) is upregulated in response to a wide variety of stimuli. Many biological roles have been attributed to Egr1， ranging from cell growth， proliferation as well as apoptosis. Once bound to the specific sequence in the promoter of target genes， Egr1 participates in regulating their expressions and executes various functions. Egr1 plays important roles in female reproduction through participating in follicular and luteal development， regulating the proliferation of mammary cells， involving in prostaglandin E biosynthesis in uterus， affecting the expression of p53 during implantation and contributing to angiogenesis in placenta. In male reproduction， Egr1 is highly expressed in prostate cancer. The regulation and function of Egr1 in mammalian reproduction were briefly reviewed.
CN
EN