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A Summarization of DNA Methyaltion Modification Research
Jia-jia Li, Charlie Degui Chen*
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: DNA methylation is an important epigenetic modification and regulates gene activity through chromatin structural alteration， DNA stability， and interacting proteins. The modification plays an essential role in normal physiological and pathological processes. Here we summarized the dynamic change of DNA modification， with an emphasis on a recent discovery that TET1 (ten-eleven translocation 1) is an oxygenase for DNA methylation. TET1 changes DNA methylation state by converting 5-methyl cytosine (5mC) to its hydroxylated form， 5-hydroxymethyl cytosine (5hmC)， and consequently， is involved in the dynamic change of DNA demethylation.
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