Roles of Oocyte-specific Linker Histone during Mammalian Embryogenesis and Genomic Reprogramming

Abstract: The changes of higher-order chromatin structure from transcriptional inactivation state to activation state influence the regulation of gene expression in early embryos which transit from maternal gene activity (MGA) to zygotic gene activity (ZGA). Oocyte-specific linker histone in mammalians as a special histone whose sequential expression patterns different from the other seven linker histone subtypes， not only takes part in the oocytic-embryonic switch during mammalian embryonenesis， also plays a critical role in genomic reprogramming. Through investigating oocyte-specific linker histone， the course of chromatin reorganization and genomic reprogramming， and the molecular mechanism of nuclear transfer will be well comprehended， which maybe make for the improvement of cloning efficiency.

CSTR: 32200.14.cjcb.2004.06.0002