Research Progress on the Intervention Effect and Potential Mechanism of Vertical Vibration Training on Microvascular Function in Type 2 Diabetic Patients
LI Miao1,2, WEN Fan1,2, FU Beilun1,2, ZHU Huan1,2*, ZHAO Peng1,2, WANG Kangfeng3, HU Jiangping3
This study was to summarize the intervention effect and potential mechanism of vertical vibra tion training on microvascular function in T2DM patients, and provide new methods and ideas for intervention and treatment of microvascular dysfunction in T2DM patients. It was concluded that (1) a single local vibration training of 15-50 Hz, 2-4 mm, lasting 5-15 min and long-term intervention lasting 2-12 weeks can improve microvascular function in T2DM patients. A single whole-body vibration training of 12-40 Hz, 2-6 mm, lasting 3-5 min or more, and a long-term intervention of 12 weeks also improved microvascular function in T2DM patients. In order to ac cumulate the effect of intervention effectively, it is recommended that T2DM patients adopt long-term intervention treatment mode. (2) vibration training mainly improves the microvascular function of T2DM patients by regulating the production of endogenous N by endothelial cells and promoting the expression of VEGF, among which increas ing the shear stress of vascular endothelial cells, inhibiting oxidative stress and improving insulin sensitivity are im portant pathways for vibration training to promote the production of NO. (3) it is suggested that subsequent studies should focus on factors such as vibration frequency, vibration location, vibration mode (local and systemic), and the degree of microvascular dysfunction of patients to deeply explore the intervention effect of vibration training, and explore the relevant mechanism of action from multiple perspectives, so as to provide more scientific and accurate evidence for the formulation of vibration training programs.
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