Glucose Metabolism in Stem Cell Fate: Focusing on Glycolysis and Oxidative Phosphorylation
SHI Liaoliao, CHEN Fei*
The metabolic mode of stem cells also undergoes significant changes in the process of fate selec tion such as proliferation and differentiation, which is crucial for regulating the differentiation potential and prolif eration status of stem cells. In this context, this article focuses on embryonic stem cells, neural stem cells, hemato poietic stem cells, mesenchymal stem cells, and other adult tissue-specific stem cells, and explores their metabolic remodeling of glycolysis and oxidative phosphorylation pathways in resting, proliferating, and differentiation states. An in-depth understanding of the complex relationship between glycolysis and oxidative phosphorylation, two ma jor energy-contributing metabolic pathways, and stem cell fate not only reveals the importance of metabolism in stem cell biology, but also provides a new perspective for stem cell therapy strategies based on metabolic regulation or pharmacological intervention.
CN
EN