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Hemoglobin Body as a Novel Subcellular Structure Enhances Chondrocyte Hypoxia Adaption
ZHANG Bo1, SUN Qiang1,2,3*
( 1 Laboratory of Cell Engineering, Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071, China; 2 Research Unit of Cell Death Mechanism (2021RU008), Chinese Academy of Medical Science, Beijing 100071, China; 3 Nanhu Laboratory, Jiaxing 314002, China)
Abstract:
Recent study indicates that massive amounts of hemoglobin, a known carrier of oxygen in erythrocytes, is produced in chondrocyte, where it can form a new structure hedy (hemoglobin body) by liquid-liquid phase separation. The production of hemoglobin in chondrocytes turns out to be dependent on Klf1 rather than the classical Hif1/2α pathway. Hemoglobin depletion leads to enhanced hypoxia that causes extensive cell death in the center of cartilaginous tissue. These results demonstrate uncover a heretofore unrecognized mechanism whereby chondrocytes survive a hypoxic environment on hedy, an oxygen storage for emergency supply.
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