Mechanism and Clinical Application of Platelet-Rich Plasma in the Treatment of Intervertebral Disc Disease
YANG Huanying1, WANG Xiangfu2*, ZHAO Daozhou2, YE Binglin2, LI Chenxu2, SHI Ruifang2
IVDD (intervertebral disc disease) has the characteristics of high incidence and high disability rate. It is popular worldwide and is one of the major diseases that seriously endanger human life and health at present. Traditional treatments, including bed rest, physical therapy, anti-inflammatory analgesics, and surgery, have only been able to relieve the patient’s clinical symptoms, but have not been able to delay or reverse the progression of IVDD. PRP (platelet-rich plasma) is a natural carrier of various growth factors. Recent studies suggest that it can inhibit inflammation, inhibit cell apoptosis, promote cell proliferation and increase extracellular matrix, and can be used as an effective treatment for IVDD. This article mainly describes the mechanism of PRP as a regenerative therapy in the treatment of IVDD, and discusses its clinical application research progress.
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