Progress in Cancer Glucose Metabolism and Targeting Therapy

Abnormal metabolism is a hallmark of cancer. Metabolic reprogramming of cancer cells is required for increased demands of energy and biomacromolecules, as well as mitigate oxidative stress to support cancer cell survival and metastasis. Remodeling of metabolic enzymes within tumor cells and tumor microenvironment reprogram glucose metabolism, which accelerates tumor initiation and development. This article reviews the functions of tumor glucose metabolic reprogramming, and proposes therapeutic strategies based on the tumor metabolic mechanisms and recent works.

CSTR: 32200.14.cjcb.2022.04.0016