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Cold-induced Apoptosis and Its Modulation Mechanism
Lan Ye, Ke Zheng, Yu Fu, Bai-Yu Wan, Wei-Xing Tong1, Xian-Ming Hu2, Mu-Yuan Zhu*
College of Life Sciences, Zhejiang University, Hangzhou 310012, China;1Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, China; 2Quzhou College of Technology, Quzhou 324000, China
Abstract: Cold and apoptosis are tightly correlated and the research on cold-induced apoptosis has become a hotspot within the transplantation medicine area. The signal transduction involved in the cold-induced apoptosis is anfractuous， either mediated or modulated by reactive oxygen species (ROS)， Ca2+， Fe2+ and cold-relevant genes in vivo. Based on the worldwide research progress， we try to generally summarize the signal transduction and modulation mechanism involved in the course of cold-induced apoptosis.
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