Dicer: the Dual Role in Tumors
TANG Yanping, SONG Guanbin*
Dicer is a type III endonuclease, which plays an important role in RNAi (RNA interference) pathway. Emerging evidence demonstrates that Dicer is involved in chromatin remodeling, heterochromatin formation and apoptotic DNA degradation in addition to small RNA production. In addition, Dicer’s transcription and protein levels should be strictly controlled, because even small changes in Dicer accumulation can lead to various pathological processes, such as carcinogenesis. Dicer can not only act as a tumor suppressor, but also promote the occurrence and development of tumor. Therefore, the elucidation of Dicer’s mechanism of action is of great significance for revealing the mechanism of tumorigenesis and tumor targeted therapy.
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