Research Progress of Signaling Pathways and Related Compounds Regulating the Differentiation and Maturation of Human Pluripotent Stem Cell-Cardiomyocytes

LIU Jinglun¹, QIN Liying¹, LIAO Lingzi¹, ZHAO Xingkun², LIU Ruimin³*

（¹School of Stomatology, Lanzhou University, Lanzhou 730000, China; ²the Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China; ³Department of Oral and Maxillofacial Surgery, Gansu Provincial People’s Hospital, Lanzhou 730000, China)

Abstract:

Cardiomyocytes derived from human pluripotent stem cells have a good prospect for basic research and clinical treatment, but their development is limited by their immature structure and function. Functional compounds can directly act on the signaling pathway during the differentiation and maturation of human pluripotent stem cells into cardiomyocytes. Adding functional compounds is a simple, effective and reproducible method. Many groups have made substantial research progress on the signaling pathways and functional compounds that promote the differentiation and maturation of human pluripotent stem cells into myocardium. This paper reviews these two aspects in order to provide guidance for future experiments.

CSTR: 32200.14.cjcb.2021.09.0017