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Progress in the Study of Anticoagulant Substances from Ticks
Zhang Xin1, Lü Shihong2, Wang Jihong1*
1School of Sciences, Liaoning Normal University, Dalian 116029, China;
2Department of Digestive Internal Medicine, the Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang 157009, China
2Department of Digestive Internal Medicine, the Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang 157009, China
Abstract: Ticks are common hematophagous ectoparasites， which can transmit a broad array of pathogens between human and animals. In order to suck the blood of parasitifer， ticks can secrete various anticoagulants from the salivary gland after a long period of evolution. Many anticoagulative substances has been found， such as inhibitors of thrombin， tissue factor， coagulation factor X (FX)， kallikrein-kinin system and platelet aggregation. These anticoagulative substances will work cooperatively and prevent blood clotting where the injury happened. This review summarized the progress in the studies of the anticoagulant substances from ticks， and would be valuable for novel antithrombotic drugs development.
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