Home > Browse Issues > Vol.38 No.12
Roles of Heme Oxygenase-1 in Diseases of Digestive System
Huang Pan, An Ke, Zhang Zhuang, Ju Xiaoli, Luo Kai, Tao Mengling, Mo Yuxi, Zhou Zhengrong*
School of Medicine, Jiangsu University, Zhenjiang 212013, China
Abstract: Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in the heme decomposition process.HO-1 and its degradative products (CO， biliverdin and Fe2+) can regulate immune function， inhibit inflammatory reaction and cell apoptosis through a variety of ways， and play potential roles in the protection of gastrointestinal diseases. This review summarizes the mechanisms of HO-1 gene expression and its regulation and the roles in the gastrointestinal and liver diseases.
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