Home > Browse Issues > Vol.36 No.11
The Progress and Applications of iPS Cells Technology in Hematopoietic Diseases
Wang Wenjun, Xing Wen, Zhou Yuan*, Yang Fengchun
State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
Abstract: Induced pluripotent stem cells (iPS cells) can be directly generated from somatic cells by introducing a defined set of transcription factors. iPS cells exhibit functional and phenotypic similarities to the embryonic stem cells (ES cells). iPS cells possess less ethical issues as compared to ES cells， and demonstrate significant advantages in regenerative medicine， disease model and drug screening. In recent years， great breakthroughs of iPS cells technology have been made in the field of hematopoietic diseases， including generation of hematopoietic stem/progenitor cells in vitro， establishment of disease models， study of the mechanism of some drug resistance and gene therapy of the monogenic diseases. In this review， we summarized the recent applications and progresses of iPS cells research in hematopoietic diseases.
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