Home > Browse Issues > Vol.36 No.11
Research Progress of DNA Methylation in Alzheimer’s Disease
Ji Huihui1#, Dai Dongjun1#, Zhou Xiaohui2, Chen Zhongming3, Li Ying4, Zhou Dongsheng3, Zhuo Renjie1,Duan Shiwei1*, Wang Qinwen1*
1Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315200, China;
2The First Affiliated Hospital of Xinjiang Medical University, Urumchi 830000, China;
3Ningbo Kangning Hospital, Ningbo 315200, China;
4Ningbo First Hospital, Ningbo 315200, China
Abstract: Alzheimer’s disease (AD) is one of the most common types of neurodegenerative diseases in the elderly. AD is characterized by progressive memory and cognitive dysfunction. The pathogenesis of AD is complex and contributed by both genetic and environmental factors. AD is closely linked with epigenetic modifications which comprise DNA methylation. Generally， gene expression will be down-regulated by promoter hypermethylation. Recent studies have found that multiple factors might exert their influences on the risk of AD by the changes of DNA methylation， such as environment， age and AD related diseases. Recently， AD related DNA methylation research has made great progress. Testing for aberrant DNA methylation in peripheral blood may be potentially applied for the prediction， diagnosis and treatment of AD. This review provides a systemic landscape of recent AD related DNA methylation studies.
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