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The Arg753Gln Polymorphism of the Human Toll-like Receptor 2 Gene and Its Association with Tuberculosis Disease in Zhejiang Han Population
Lei Jin, Shi-Ping Ding, Xiu-Fang Zhu1, Jian-Ping Zhong2, Ji-Cheng Li*
Institute of Cell Biology, Zhejiang University, Hangzhou 310031, China; 1Yiwu Central Hospital, Yiwu 322000, China; 2Shaoxing Fourth Hospital, Shaoxing, 312007, China
Abstract: Toll-like receptor 2 (TLR2) plays a critical role in immune response to mycobacteria. In order to know the TLR2 Arg753Gln single nucleotide polymorphism (SNP) and the relationship with the developing of tuberculosis in Zhejiang Han population， we collected the blood samples from 170 TB patients compared with 199 ethnically and age-matched healthy blood donors. Polymerase chain reaction with sequence specific primer method (PCR-SSP) was applied to detect the TLR2 Arg753Gln polymorphism. The G/G genotype of Arg753Gln polymorphism was observed in 58.23% and 84.2% in TB patients and the controls， respectively. And the G/A genotype in the cases was much greater， 41.77%， compared with 15.8% in the controls. Statistically significant difference was found between the two groups， P<0.001. Moreover， no one in either group was homozygous for the mutation (A/A). The present data suggests that the polymorphism of the TLR2 gene in Zhejiang Han population has its specific distribution trait. And it influences the risk of developing tuberculosis.
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