Application of Lipidomics in Medicine and Drug Development

Abstract: Lipidomics， aiming to analyze the lipids and their interacting molecules in system level， is a sub emerging field in the metabonomics research field. Different lipids interact with each other and make up a complicated lipid metabolic network which is involved in many physiological processes. Through analyzing the lipid profiles under different physiological conditions， lipidomics research can indicate the changes of the lipid metabolic network and the lipid-based biomarkers that contribute to the changes. With the development of mass spectrometry technology， especially the electrospray ionization mass spectrometry， lipids and in particular the phospholipids can be analyzed in a high throughput manner， which promotes the advances of lipidomics research. Currently， studies on the lipidomics level have been employed in many medicine related fields， such as the discovery of drug targets and the leading chemicals， the effecting mechanism of the drugs and so on. Thus lipidomics opens promising opportunities for disease diagnosis and treatment， as well as drug research and development.

CSTR: 32200.14.cjcb.2007.02.0001