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The Advances in Hippo Pathway Association with Cancer
Shi Mengjie, Shao Songjun, Li Jiemei, Zhou Yanfang*, Huang Peichun*
Department of Pathophysiology, Guangdong Medical College, Zhanjiang 524023, China
Abstract: The Hippo pathway is important for the regulation of organ size， cell proliferation and apoptosis.In recent studies， YAP (Yes-associated protein)， as a transcription co-activator of the Hippo pathway， is involved in the development of tumor， and its overexpression promotes cell malignant transformation. Understanding the relationship between the Hippo pathway and cancer can provide a new perspective for the prevention and treatment of cancer.
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