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Function of HOPS Complex Proteins in Autophagy Process
Hu Wanqiu1#, Lin Zhixiang2#, Chen Lilian3, Yan Xianghua4, Chen Fang1*
1School of Life Science, Sichuan University, Chengdu 610064, China; 2School of Life Science, Tsinghua University, Beijing 100064,China; 3School of Biology, China Agricultural University, Beijing 100083, China; 4
Abstract: Autophagy is a lysosome dependent intracellular degradation process， which engulfs molecules or organelles to lysosome and then degraded to monosaccharide or amino acid for reuse. We investigated that in HOPS complex genes vps39 and vps41 loss yeasts， there were extensive accumulation of GFP-ATG8， and the fusion processes of autophagy were blocked. But in other two HOPS complex genes vps16 and vps18 loss yeasts， the fusion processes had little change. Moreover， in vps16 and vps18 double loss cells， the fusion processes were not disturbed. Therefore， our work provided a new insight to understand the function of HOPS complex and the fusion process between autophagosome and lysosome.
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