Mediator Complex——Central Controller of Eukaryotic Transcription

Abstract: Mediator Complex is an evolutionarily conserved， multiprotein complex. As an essential part of the Pol II transcriptional machinery， Mediator Complex functions as a molecular bridge to transduce regulatory information from DNA-binding transcription factors to Pol II. In metazoan cells， different transcription factors， in response to respective signaling pathways， physically interact with different Mediator subunits to control expression of the specific set of genes. In addition， Mediator Complex could interact with many cofactors involved in transcriptional and epigenetic regulation. These multiple and dynamic interactions allow Mediator Complex to control cell growth， proliferation， differentiation， and diverse biological processes by intergrating signaling and delivering outputs to downstream genes. This review mainly focuses on the recent progress in understanding the mechnisms of Mediator Complex in regulating eukaryotic transcription.

CSTR: 32200.14.cjcb.2011.06.0001