Developments in Regulation of Adipocytes Differentiation

Abstract: The epidemics of obesity and other related metabolic diseases have focused worldwide attentions on adipose tissue deposition. From the cellular level point of view， body fat content is a macro expression of adipocytes number and single adipocye volume. The number of adipocytes is decided by adipogenic differentiation rate of pluripotent stem cells， and a single cell volume is related to its triglyceride accumulation and differentiation degree. Therefore， understanding the cellular and molecular basis of adipocyte differentiation is crucial to develop strategies for the treatment of lipid metabolic diseases. This review highlights recent progress in the field of adipocytes differentiation， including the origin of adipocytes， the in vitro investigation models， the general rules of adipocytes differentiation and its regulation.

CSTR: 32200.14.cjcb.2010.05.0002