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The Function of Heterogeneous Nuclear Ribonucleoproteins in pre-mRNA Processing
Jia Huang, Xian-Hua Chen, Ping Xu*
Laboratory of Genomic Phyisology and Brain Research Center, Fudan University, Shanghai 200433, China
Abstract: Heterogeneous nuclear ribonucleoprotein (hnRNP) is a family of proteins that are highly expressed in eukaryotic cells and diffusely distributed in the nucleus. Various hnRNP proteins share similar structural characteristics and play a variety of functions in regulation of gene expression， including transcription， pre-mRNA splicing， mRNA export and mRNA decay. In this review， we briefly summarize the recent progresses regarding the function of hnRNP in pre-mRNA processing.
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