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Ribosome-inactivating Proteins in Bitter Gourd (Momordica charantia)
SUN Hai Yan, HU Jia Shu1, WANG Qiao Mei*
Department of Horticulture, Zhejiang University, Hangzhou 310029, China; 1Institute of Biochemistry, Zhejiang University, Hangzhou 310029, China
Abstract: Ribosome-inactivating proteins (RIPs) are a group of protein toxins that inhibit protein synthesis by cleaving the largest rRNA of ribosomes. RIPs can be classified into two types， TypeⅠand typeⅡRIP. Several TypeⅠRIPs， including α-Momorcharin， β-Momorcharin and MAP30 have been identified in Momordica charantia. The antitumor， antiviral and anti-AIDS properties of these proteins have aroused wide interest in this area. Progress in the study of RIPs in bitter gourd and its application are reviewed in this paper.
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