Advances and Prospects of Cell Therapy for Parkinson’s Disease

XIE Silun¹, HONG Guodai², LI Yiheng¹, WU Zhenyi¹, XIAO Yang³*

(¹Yimei Era (Shenzhen) Biotechnology Co., Ltd., Shenzhen 518081, China; ²Department of Medical Oncology, Luohu People’s Hospital, Shenzhen 518002, China; ³Department of Rehabilitation Medicine III, Mingzhou Rehabilitation Hospital, Guangzhou 510030, China)

Abstract:

PD (Parkinson’s disease) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, with a notably higher prevalence in aging populations. Current therapeutic interventions predominantly alleviate motor symptoms but fail to halt the ongoing neuronal degeneration or provide a disease-modifying cure. This review provides an in-depth analysis of PD pathophysiology and the limitations of conventional treatments. It systematically evaluates the therapeutic potential of diverse cell types—including neural stem cells, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells—in restoring neurological function via mechanisms such as dopaminergic neuron replacement and neurotrophic factor secretion. Furthermore, it explores the synergistic value and clinical prospects of combinatorial therapeutic strategies for PD management.

CSTR: 32200.14.cjcb.2026.08.0011