Research Progress of Adipocyte Death
ZHANG Diyue1,2#, SONG Jianfeng1,2#, DENG Tuo1,2,3*
Adipocyte death is a key driver of chronic adipose tissue inflammation and the formation of CLS (crown-like structure), and is closely associated with obesity and various chronic diseases. Adipocyte death promotes macrophage polarization toward a pro-inflammatory phenotype and contributes to adipose tissue remodeling through the release of signaling molecules, playing important roles in both physiological and pathological conditions. This review focuses on four major forms of cell necrosis, apoptosis, pyroptosis, and ferroptosis, along with their molecular characteristics, and summarizes the multifactorial causes of adipocyte death. The inflammatory cascades triggered by adipocyte death drive the development and progression of diseases such as insulin resistance and malignancies. A deeper understanding of the molecular regulatory networks and crosstalk among these cell death pathways may provide a theoretical basis and potential therapeutic targets for the prevention and treatment of metabolic disorders.
CN
EN