Advances in the Application of Intestinal Organoids to Host-Microbe Interaction Studies
LIU Quanmin, HUANG Ping, TAN Jingjing, YU Yingxuan, DENG Yifang*
Intestine is an important multifunctional organ of human body, and its interaction with microorganism plays a key role in maintaining human health. The traditional research model has obvious limitations, and it is difficult to accurately reflect the human intestinal environment. IO (intestinal organoid) has similar composition, structure and function to intestinal epithelium, and can maintain the physiological characteristics of primary tissues to a certain extent, which has become a potential platform for studying HMI (host-microbe interaction). This paper mainly summarizes the research progress of IO model, its application in HMI research, the current challenges it faces and coping strategies, in order to provide scientific reference for related mechanism research.
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