Research Progress on Chondroitin Sulfate Proteoglycans in the Nervous System
HUANG Haiyue*, MA Wenqian, HE Wenxin
CSPGs (chondroitin sulfate proteoglycans), as key components of the extracellular matrix in the nervous system, have become a research hotspot in the field of neuroscience in recent years. Interdisciplinary research in molecular biology, glycomics, and neural regenerative medicine has revealed that CSPGs function not merely as an “inhibitory barrier” but as a “dynamic regulatory network.” This article will review the research prog ress of CSPGs in neuroscience from five aspects: CSPGs in the nervous system, CSPGs and neural development, CSPGs and glial scarring, the role of CSPGs in neurodegenerative diseases, and the therapeutic potential of CSPGs in neural injury.
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