Research Progress of KLF6 in Immune Regulation and Diseases
ZHANG Xianzhen, XIAO Rong*
The KLF (Krüppel-like factor) family contains 18 members, among which, member KLF6, also known as ZF9 (zinc finger factor 9), was initially isolated from placental tissue. It consists of an acidic domain at the N-terminal, an intermediate domain rich in serines/threonines, and a DNA-binding domain at the C-terminal. As a transcriptional regulatory factor, KLF6 is widely expressed in various types of normal tissues. When the microen vironment in vivo changes, KLF6 expresses abnormally, and participates in regulating various processes, including cell proliferation, differentiation, apoptosis, pyroptosis and inflammatory responses, etc. To further reveal the regu latory role and mechanism of KLF6 in immune responses and various related diseases, the structural characteristics of KLF6 and its close relationships with macrophage polarization and mobility function, as well as diseases includ ing tumors, acute kidney injury, neuroinflammation, immune rejection, liver ischemia-reperfusion injury, endothe lial cell inflammation, etc, were reviewed in the present paper. These findings suggest that KLF6 may serve as a biomarker for clinical diagnosis and as a novel therapeutic target for the aforementioned diseases.
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