The Role of AMPK in the Prevention and Treatment of Parkinson’s Disease by Exercise
CHEN Meilian, ZHOU Wenhui*
PD (Parkinson’s disease) is a common neurodegenerative disorder in middle-aged and elderly individuals, which not only severely impairs the patients’ daily functional abilities but also imposes a significant so cial and medical burden. AMPK (AMP-activated protein kinase) is a key regulatory molecule in bioenergy metabo lism, and its functional regulation is closely related to the pathological process of PD. Exercise, as a non-pharmaco logical intervention, can effectively activate AMPK and its downstream complex signaling networks, playing a key role in the protection of DA (dopamine) neurons by alleviating mitochondrial dysfunction, promoting autophagic clearance, and resisting oxidative stress through multiple pathways. Therefore, this paper reviews the role of AMPK in exercise-based prevention and treatment of PD, providing new perspectives for a deeper understanding of the molecular mechanisms underlying exercise interventions in PD and laying a theoretical foundation for developing AMPK-targeted PD intervention strategies.
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