Research Progress on Exercise-Mediated Multi-Organ Synergy in the Improvement of Metabolic-Associated Fatty Liver Disease
WEI Huazhu1, CHEN Wei1*, LI Tao1, WANG Yirong1, LIU Wenfeng2
Exercise, as a first-line strategy for the prevention and treatment of non-alcoholic fatty liver disease, features multi-target and systemic benefits. By coordinating the interaction of multiple organs rather than acting solely on the liver, it has the unique advantage of improving hepatic lipid deposition without increasing the metabolic burden. It is widely used in clinical practice for the prevention and treatment of insulin resistance, obesity and related metabolic disorders. MAFLD, as a multi-organ metabolic network disorder disease, its occurrence and development are closely related to the functional disorders of organs such as the liver, fat, muscle and intestine. Exercise can effectively reverse the systemic metabolic homeostasis imbalance by inducing multiorgan “dialogue”. Due to its powerful multi-system regulatory capabilities, exercise has become a core intervention method for improving liver lipid metabolism, inhibiting inflammatory responses, and optimizing intestinal microecology. This article systematically reviews the role and mechanism of exercise-mediated multi-organ collaboration in the improvement of MAFLD, and looks forward to the limitations of current research and future directions.
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