Advances in the Research of K63 Ubiquitination in Gastric Cancer
CHEN Yunqi, ZHANG Pengshan, HUANG Chen*
K63-linked ubiquitination is an important post-translational protein modification that plays a crucial role in regulating various cellular processes. It is also involved in several human diseases, including cancer. Gastric cancer is one of the three most prevalent malignant tumors in China. This review discusses the formation of K63 ubiquitination and the regulatory mechanisms of E2 enzymes, E3 ligases, and deubiquitinases. This review also explores the significant role of K63 ubiquitination in the development and progression of gastric cancer. K63-linked ubiquitination modulates biological processes, such as cell proliferation and migration, autophagy regulation, metabolic reprogramming, DNA damage response, proteasomal degradation, immune response, and inflammation modulation. These processes affect the proliferation, migration, and invasion of gastric cancer cells. Research on K63-linked ubiquitination has provided potential diagnostic and therapeutic targets for gastric cancer. This review summarizes progress on K63-related ubiquitinating and deubiquitinating proteins and how K63 ubiquitination regulates gastric cancer. This information can be used to identify potential diagnostic and therapeutic targets for gastric cancer.
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