Applications of Plant-Derived Extracellular Vesicles in Disease Treatment
YE Yuqi, QIN Yuan, ZHOU Xiumei*
PDEVs (plant-derived extracellular vesicles) are phospholipid bilayer vesicles with a diameter of 30-200 nm secreted by plant cells, composed of proteins, lipids, nucleic acids, and secondary metabolites, and can be absorbed by human cells. In recent years, PDEVs have demonstrated unique advantages and significant thera- peutic effects in the field of disease treatment. This review summarizes the biogenesis, composition, and preparation methods of PDEVs, and highlights their applications in the treatment of neurodegenerative diseases, bone and joint diseases, inflammatory bowel disease, cancer, and respiratory system diseases. Additionally, it discusses the chal- lenges of large-scale production and stability of PDEVs to promote clinical translation, and provides an outlook on future research directions in this rapidly developing field.
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