Research Progress on the Molecular Mechanism of Cell Movement Guided by Pseudopodia
FU Yujia1,2, DING Xue1, SHI Limin1, CHEN Xiaobo1, GAO Runchi1*
Cell motility is fundamental for organisms to maintain normal physiological functions, adapt
to environmental changes, and participate in complex processes such as tissue development and immune respons
es. As a key structure in cell movement, pseudopodia plays an indispensable and central role. Pseudopodia are
temporary protrusions formed by the dynamic reorganization of the cell membrane and cytoskeleton, and they
are widely present in various cell types. By extending, sensing, and adapting to the environment, they participate
in biological processes such as cell-matrix interactions, signal transduction, and phagocytosis. In recent years,
with advances in cell biology and molecular biology techniques, the mechanisms underlying pseudopodia forma
tion and their regulatory networks in cell motility have been gradually uncovered. This article reviews the major
types and functions of pseudopodia, explores the complex molecular regulatory networks governing pseudopodia
during cell movement, and discusses recent progress in mathematical modeling of pseudopodia. It provides im
portant insights for a deeper understanding of the biological functions of pseudopodia and their applications in
cell motility research.
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