Metabolic Crosstalk between Tumor Cells and Tumor-Associated Macrophages
WANG Huanhuan, DONG Wenhao, LIU Fang, CHEN Che*
TAMs (tumor-associated macrophages) are one of the most abundant cell populations in the TME (tumor microenvironment) and play a key role in tumorigenesis, chemoresistance, immune evasion, and me tastasis. There is an important interaction between TAMs and tumor cells: metabolic reprogramming can confer a survival advantage on tumor cells in TME, and corresponding metabolic by-products can affect the function of TAMs. In addition, TAMs undergo metabolic reprogramming in response to signals present in the TME, which can affect their function and cancer progression. Identifying metabolic changes that affect the complex interactions between tumor cells and TAMs is an important step in the exploration of new treatments that enhance their tumori cidal potential. This article summarizes the metabolic alterations during tumor cell-TAM interactions, highlighting potential targets for cancer treatment.
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