Study on the Mechanism of Lactic Acid Metabolism and Lactylation in Breast Cancer Cells
WANG Guixia1, WU Guotai2, YANG Binfeng1, HUANG Bangrong1, ZHANG Zhiming1*
Breast cancer is the most common malignant tumor in women worldwide and the leading cause of death among female cancer patients. Recent studies have shown that breast cancer is associated with elevated lactate levels, so it is essential to study the physiological effects of lactate on breast cancer. Lactate is a product of glycolysis and an important energy source for mitochondrial respiration. Lactate moves between cells and plays an important role in cell communication, and functions in energy metabolism. Lactate can regulate gene transcription through histone and non-histone lactylation and participate in tumor proliferation, and other biological processes. Lactate can promote breast cancer progression by shaping the acidic tumor microenvironment and recruiting im mune cells. Targeting lactate production, regulating lactate transport, and lactylation may be potential therapeutic methods for breast cancer. This article provides a comprehensive review and summary of the role of lactic acid metabolism-lactylation in breast cancer, aiming to provide references and directions for future research.
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