Research Progress and Prospect of Chimeric Antigen Receptor Therapy Targeting Non-Traditional T Cell Subsets
YANG Yifan1,2, LI Yuning2, CHEN Xinglong2, LUO Yongzhong2, CHENG Tianli2, ZHANG Lemeng2*
CAR-T therapy (chimeric antigen receptor T-cell therapy) has demonstrated remarkable efficacy in the treatment of hematological malignancies and has been established as an important strategy in tumor immu notherapy. However, its current application is mainly limited to hematological tumors, and it faces issues such as limited indications and uncertainties regarding long-term efficacy and safety, which restrict its broader clinical ap plication. To overcome these limitations, researchers are actively exploring innovative approaches to improve CAR T cell therapy. Among them, the development of novel chimeric antigen receptor cells targeting non-traditional T cell subsets is emerging as a highly promising research direction. This review aims to systematically review the lat est research progress in chimeric antigen receptor cells targeting non-traditional T cell subsets, analyze their unique advantages and potential in overcoming the bottlenecks of traditional CAR-T therapy, and discuss the current chal lenges and future development directions.
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