The Role of Programmed Cell Death-Related Non-Coding RNA in the Occurrence and Development of Ovarian Cancer

GAN Decheng¹, WANG Guixia², WU Guotai³, ZHANG Lili^1*

(¹Department of Traditional Chinese Medicine Classics, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; ²Department of Oncology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; ³Longyao Industry Innovation Research Institute, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China)

Abstract:

OC (ovarian cancer) is one of the most lethal gynecological malignancies, with the highest mor tality rate among female cancers. PCD (programmed cell death) is an orderly, reversible, and highly regulated cel lular process, including pyroptosis, autophagy, ferroptosis, and apoptosis, which plays crucial regulatory roles in the progression of ovarian cancer. ncRNAs (non-coding RNAs) are key players in maintaining cellular and tissue homeostasis, and a growing body of research indicates their involvement in various diseases, including cancer ini tiation and progression. Increasing attention has been focused on the roles of PCD-related ncRNA—such as miRNA (microRNA), circRNA (circular RNA), and lncRNA (long non-coding RNA) in ovarian cancer. This review sys tematically summarizes the relationship between PCD-associated ncRNAs and OC progression. Understanding the functions of ncRNA in pyroptosis, autophagy, ferroptosis, apoptosis, and ovarian cancer development may provide novel insights for exploring potential therapeutic biomarkers in the future.

CSTR: 32200.14.cjcb.2025.10.0023