Application and Prospect of Organoid Technology in Tissue Regeneration

This review systematically explores the critical role and future prospects of organoid technology in tissue regeneration. Given the limited self-repair capacity of adult organs, solid organ transplantation remains an effective treatment for end-stage organ failure, yet it is constrained by donor shortages and postoperative complications. With its ability to mimic organ structure and function, organoid technology is emerging as a vital tool in regenerative medicine. This paper highlights the application of organoid transplantation in the regeneration of organs such as the intestine, liver and pancreas, with particular emphasis on the importance of vascularization in enhancing organoid survival and functional maturation. Moreover, biomaterials and decellularized scaffolds also play a key role in supporting organoid structure and facilitating successful transplantation. Despite its broad potential in tissue regeneration, organoid technology still faces challenges, including improving functionality, stability, and clinical safety. Looking ahead, organoids hold great promise in tissue repair and personalized therapy, offering new avenues for organ replacement and disease treatment.

CSTR: 32200.14.cjcb.2025.09.0022